Kawasaki-like Syndrome: Abacavir Hypersensitivity?
نویسندگان
چکیده
منابع مشابه
Abacavir hypersensitivity reaction.
A hypersensitivity reaction occurs in association with initiation of abacavir therapy as part of combination antiretroviral therapy in approximately 3.7% of patients. The reaction is possibly the result of a combination of altered drug metabolism and immune dysfunction, which is poorly understood. White patients appear to be at higher risk and patients of African descent at lower risk of abacav...
متن کاملCytokine profiling in abacavir hypersensitivity patients.
BACKGROUND Abacavir hypersensitivity in genetically susceptible individuals implicates an abacavir-specific T-cell response to either the parent drug or a metabolite generated in vivo. We have analysed the cytokine profile in antigen-presenting cells and the T-lymphocytes that are involved in the pathological immune response to abacavir. METHODS In this study, we compared abacavir-specific cy...
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Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase en...
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Introduction: Olanzapine (Zyprexa) has become one of the most commonly prescribed atypical antipsychotic drug in Iran, at least in part due to its low potential to cause extra-pyramidal side effects. Case: A 54-year-old man, who was a known case of schizophrenia from 10 years ago and within the recent years, was under periodic medical treatment by antipsychotic drugs. Conclusion: Neurologi...
متن کاملKawasaki syndrome
Coronary aneurysms were demonstrated echocardiographically in 34 of 186 patients who presented with Kawasaki syndrome between 1979 and 1983. The aneurysms were confirmed by selective coronary angiography in 27 patients and by postmortem examination in one. The 27 surviving patients with proven aneurysms were followed for 2 to 40 months (mean 15), during which they received low dose (5 to 10 mg/...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2002
ISSN: 1058-4838,1537-6591
DOI: 10.1086/324094